Understanding Your Options When Taking 阿斯匹林 and Other Antiplatelet Drugs

Many people who have had a heart attack and stroke – and people seeking to avoid those events – are treated with what’s known as dual antiplatelet therapy. Simply put, that means taking aspirin along with a second drug to prevent blood clotting.

双重抗血小板治疗, 称为DAPT, often is prescribed for people who have had heart attacks, are treated with stents in their coronary arteries, and some patients who undergo coronary artery bypass surgery. 

阿斯匹林 is an antiplatelet agent that probably will be prescribed for the rest of a person’s life, if they fall into one of these categories and don’t have strong reasons not to take it. A second type of antiplatelet agent, called a P2Y₁₂ inhibitor, is usually prescribed for months or years in addition to aspirin.

You may be prescribed one of the following: clopidogrel, 普拉格雷, ticagrelor, 噻氯匹定或康格乐. Which one you take and how long you take it depends on your personal risks for heart attack, stroke or other cardiovascular events and other factors that you’ll discuss with your health care professional.

The costs of each medication differ as well, which is another factor to discuss with your health care professional.

我需要接受多长沙巴足球体育平台的DAPT治疗?

How long you need to take this medicine depends on why it’s being prescribed and your future risk of blood clots and bleeding.

• If you had a heart attack, it is recommended that you be on it for at least a year. 如果你没有很高的出血风险, taking it longer may lower your risk of future heart attack.
• If you received a “bare metal” stent and you are a high bleeding risk, your health care professional may decide to give you a P2Y₁₂ inhibitor for a shorter period to decrease the chances of bleeding. 然而, 如果你出血的风险较低, you may have been treated with a drug-eluting stent, and you may be on DAPT for 6-12 months or longer. 如果你没有很高的出血风险, a longer duration may lower your risk of future heart attack and clotting of the stent. It’s important for you to take the medication as prescribed. Stopping it on your own can lead to increased risk of clots forming inside the stent, 尤其是在最初的几个月.
• If you had CABG, you may be treated with a P2Y₁₂ 手术后服用抑制剂一年.

注意药物相互作用

People on DAPT should be mindful of the many interactions that can occur when taking multiple medications. Some over-the-counter medications can even create problems.

Ibuprofen and other non-steroidal inflammatory drugs can lead to problems with P2Y₁₂ 抑制剂.

当然, 许多其他药物，甚至一些食物 – can interact negatively with medications.

For example, grapefruit can affect the way some cholesterol medications work. And some blood thinners and anticoagulants such as warfarin can react to over-the-counter drugs like ibuprofen.

 可下载的病人单: 什么是DAPT? (PDF)